B-N-acetilglukozaminil-glikopeptid b-1,4-galaktoziltransferaza
| B-N-acetilglukozaminil-glikopeptid b-1,4-galaktoziltransferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.4.1.38 | ||||||||
| CAS broj | 37237-43-7 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
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B-N-acetilglukozaminil-glikopeptid b-1,4-galaktoziltransferaza (EC 2.4.1.38, UDP-galaktoza---glikoprotein galaktoziltransferaza, glikoprotein 4-beta-galaktozil-transferaza, beta-N-acetil-beta1-4-galaktoziltransferaza, tiroid glikoprotein beta-galaktoziltransferaza, glikoprotein beta-galaktoziltransferaza, tiroid galaktoziltransferaza, uridin difosfogalaktoza-glikoprotein galaktoziltransferaza, beta-N-acetilglukozaminil-glikopeptid beta-1,4-galaktoziltransferaza, GalT, UDP-galaktoza:N-acetil-beta-D-glukozaminilglikopeptid beta-1,4-galaktoziltransferaza, UDP-galaktoza:N-acetil-beta-D-glukozaminilglikopeptid 4-beta-galaktoziltransferaza) je enzim sa sistematskim imenom UDP-alfa-D-galaktoza:N-acetil-beta-D-glukozaminilglikopeptid 4-beta-galaktoziltransferaza.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
- UDP-alfa-D-galaktoza + N-acetil-beta-D-glukozaminilglikopeptid UDP + beta-D-galaktozil-(1->4)-N-acetil-beta-D-glukozaminilglikopeptid
Terminalni N-acetil-beta-D-glukozaminil ostataci u polisaharidima, glikoproteinima i glikopeptidima mogu da deluju kao akceptori.
Reference
[уреди | уреди извор]- ^ Beyer, T.A., Sadler, J.E., Rearick, J.I., Paulson, J.C. and Hill, R.L. (1981). „Glucosyltransferases and their uses in assessing oligosaccharide structure and structure-function relationship”. Adv. Enzymol. 52: 23—175. PMID 6784450.
- ^ Blanken, W.M., Hooghwinkel, G.J.M. and van den Eijnden, D.H. (1982). „Biosynthesis of blood-group I and i substances. Specificity of bovine colostrum β-N-acetyl-D-glucosaminide β1→4 galactosyltransferase”. Eur. J. Biochem. 127: 547—552. PMID 6816588.
- ^ Blanken, W.M. & van den Eijnden, D.H. (1985). „Biosynthesis of terminal Gal α 1→3Gal β 1→4GlcNAc-R oligosaccharide sequences on glycoconjugates. Purification and acceptor specificity of a UDP-Gal:N-acetyllactosaminide α 1→3-galactosyltransferase from calf thymus”. J. Biol. Chem. 260: 12927—12934. PMID 3932335.
- ^ Spiro, M.H. & Spiro, R.G. (1968). „Glycoprotein biosynthesis: studies on thyroglobulin. Thyroid galactosyltransferase”. J. Biol. Chem. 243: 6529—6537. PMID 5726898.
Literatura
[уреди | уреди извор]- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
Spoljašnje veze
[уреди | уреди извор]- Beta-N-acetylglucosaminylglycopeptide+beta-1,4-galactosyltransferase на US National Library of Medicine Medical Subject Headings (MeSH)
